THE 2-MINUTE RULE FOR SBS88

In vitro studies of human most cancers cell strains have indicated that SBS2/SBS13 mutagenesis is episodic, developing in bursts with extended periods of intervening silence31. To investigate regardless of whether APOBEC mutagenesis in regular compact intestine cells in vivo is episodic, we examined crypt phylogenetic trees and found that APOBEC-be